Elastic properties of granular materials

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN019852 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Development of the health and economic consequences of smoking interactive model

Objective-To describe the health and economic consequences of smoking model, a user friendly, web based tool, designed to estimate the health and economic outcomes associated with smoking and the benefits of smoking cessation. Results-An overview of the development of the model equations and user interface is given, and data from the UK are presented as an example of the model outputs. These results show that a typical smoking cessation strategy costs approximately pound 1200 per life year saved and pound 22 000 per death averted. Conclusions-The model successfully captures the complexity required to model smoking behaviour and associated mortality, morbidity, and health care costs. Furthermore, the interface provides the results in a simple and flexible way so as to be useful to a variety of audiences and to simulate a variety of smoking cessation methods

A low noise, high thermal stability, 0.1 K test facility for the Planck HFI bolometers

We are developing a facility which will be used to characterize the bolometric detectors for Planck, an ESA mission to investigate the Cosmic Microwave Background. The bolometers operate at 0.1 K, employing neutron-transmutation doped (NTD) Ge thermistors with resistances of several megohms to achieve NEPs~1×10^(–17) W Hz^(–1/2). Characterization of the intrinsic noise of the bolometers at frequencies as low as 0.010 Hz dictates a test apparatus thermal stability of 40 nK Hz^(–1/2) to that frequency. This temperature stability is achieved via a multi-stage isolation and control geometry with high resolution thermometry implemented with NTD Ge thermistors, JFET source followers, and dedicated lock-in amplifiers. The test facility accommodates 24 channels of differential signal readout, for measurement of bolometer V(I) characteristics and intrinsic noise. The test facility also provides for modulated radiation in the submillimeter band incident on the bolometers, for measurement of the optical speed-of-response; this illumination can be reduced below detectable limits without interrupting cryogenic operation. A commercial Oxford Instruments dilution refrigerator provides the cryogenic environment for the test facility

Some recent results in aerospace vehicle trajectory optimization techniques

Algorithms and computation techniques for solving trajectory optimization problem

Potential Sinks for Geologic Storage of CO2 Generated in the Carolinas

This document summarizes a scoping study of the current state of knowledge of carbon storage options for our geographic area. The focus is on one aspect of carbon capture and storage—identification of deep saline aquifers in which carbon dioxide (CO2 ) generated in the Carolinas might be stored. The study does not address other aspects of CO2 storage projects, such as capture and compression of the gas, well construction and development, or injection. Transport of CO2 is touched upon in this study but has not been fully addressed. The information contained in this document is primarily from review of published geologic literature and unpublished data. No field data collection has been completed as part of this study. Further work will be necessary to increase confidence in the suitability of the potential CO2 storage sites identified in this report. This study does not address the regulatory, environmental, or public policy issues associated with carbon storage, which are under development at this time.Duke Energy, Progress Energy, Santee Cooper Power, South Carolina Electric and Gas, Electric Power Research Institute (EPRI), Southern States Energy Board (SSEB)Bureau of Economic Geolog

Initial test results on bolometers for the Planck high frequency instrument

We summarize the fabrication, flight qualification, and dark performance of bolometers completed at the Jet Propulsion Laboratory for the High Frequency Instrument (HFI) of the joint ESA/NASA Herschel/Planck mission to be launched in 2009. The HFI is a multicolor focal plane which consists of 52 bolometers operated at 100 mK. Each bolometer is mounted to a feedhorn-filter assembly which defines one of six frequency bands centered between 100-857 GHz. Four detectors in each of five bands from 143-857 GHz are coupled to both linear polarizations and thus measure the total intensity. In addition, eight detectors in each of four bands (100, 143, 217, and 353 GHz) couple only to a single linear polarization and thus provide measurements of the Stokes parameters, Q and U, as well as the total intensity. The measured noise equivalent power (NEP) of all detectors is at or below the background limit for the telescope and time constants are a few ms, short enough to resolve point sources as the 5 to 9 arc min beams move across the sky at 1 rpm

Potential sinks for geologic storage of carbon dioxide generated by power plants in North and South Carolina

Duke Energy Progress Energy Santee Cooper Power SCANA CorporationBureau of Economic Geolog

Towards the general mechanistic prediction of community dynamics

”What controls the distribution and abundance of organisms”? This question, at the heart of the dynamics of ecological communities, would have been familiar to the earliest ecologists. Having lain effectively abandoned for many years, community dynamics today is a vibrant research topic of great conceptual interest with practical import for conservation, ecological management, ecosystem services and the responses of ecological communities to climate change.  We describe how modern coexistence theory can be applied to predict community dynamics through the use of demography. We explore the challenges that limit the deployment of this demographic framework, and the tools from phylogenetic and functional ecology that have been used to surmount them.  Finding existing tools not altogether sufficient, we propose the use of ‘hard’ functional traits and physiological tolerances of environmental conditions and low resource availability to extend the demographic framework so that the dynamics of a broader range of ecological communities can be accurately predicted.  We illustrate these new approaches with two case studies. Given the urgent need to accurately forecast the dynamics of ecological communities, we hope that many ecologists will adopt these tools

Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling

Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signaling may be synergistic with activated NRAS in the pathogenesis of CMN syndrome. Some familial pre-disposition suggests a germ-line contribution to CMN syndrome, as does variability of neurological phenotypes in individuals with similar cutaneous phenotypes. Accordingly, we performed exome sequencing of germ-line DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations. A murine model harboring activated NRASQ61K and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK inhibition is a potential candidate therapy for patients with this debilitating condition